Bulletin N°68

Boosting angiotensin-converting enzyme (ACE) in microglia protects against Alzheimer's disease in 5xFAD mice - Nature Aging – June 2025

Andrew R. Gomez et al.

PMID: 40490625

Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures - Cell Reports – June 2025

Alexandra M Lish et al. 

PMID: 40471789

Identification of the velum interpositum as a meningeal-CNS route for myeloid cell trafficking into the brain - Neuron – May 2025

Lindsay A. Hohsfield et al.

PMID: 40466634

Mutant THAP11 causes cerebellar neurodegeneration and triggers TREM2-mediated microglial activation in mice - Journal of Clinical Investigation – June 2025

Eshu Ruan et al.

PMID: 40459937

 

Anti-pyroglutamate-3 Aβ immunotherapy engages microglia and inhibits amyloid accumulation in transgenic mouse models of Aβ amyloidosis - Acta Neuropathologica – June 2025

Fan Liao et al.

PMID: 40455292

4E-BP1–dependent translation in microglia controls mechanical hypersensitivity in male and female mice - Journal of Clinical Investigation – June 2025

Kevin C Lister et al.

PMID: 40454470

Microglial STING is a central safeguard against neurological decline with age Cell Reports – May 2025

Katherine B. Sulka et al.

PMID: 40450689

Ultrabright ratiometric Raman-guided epilepsy surgery by intraoperatively visualizing proinflammatory microglia - Cell Reports Medicine – May 2025

Cong Wang et al.

PMID: 40449482

Glioblastoma shift from bulk to infiltrative growth is guided by plexin-B2-mediated microglia alignment in invasive niches - Nature Cancer – June 2025

Sangjo Kang et al.

PMID: 40442367

CSF proteomics of semorinemab Alzheimer's disease trials identifies cell-type specific signatures - Brain – May 2025

Alyaa M Abdel-Haleem et al.

PMID: 40435316

Inactivation of the PHD3-FOXO3 axis blunts the type I interferon response in microglia and ameliorates Alzheimer’s disease progression - Science Advances – May 2025

Manuel A Sanchez-Garcia et al.

PMID: 40435260

Nanoimmunomodulation of the Aβ-STING feedback machinery in microglia for Alzheimer’s disease treatment - PNAS - April 2025

Limin Tian et al.

PMID: 40434641

Thalamic atrophy in multiple sclerosis is associated with tract disconnection and altered microglia - Acta Neuropathologica – May 2025

Carla Rodriguez-Mogeda et al.

PMID: 40434526

Neoantigens combined with in situ cancer vaccination induce personalized immunity and reshape the tumor microenvironment - Nature Communications – May 2025

Kuanhan Feng et al

PMID: 40450037

MicroRNA-142-3p shuttling in extracellular vesicles marks regulatory T cell dysfunction in multiple sclerosis - Science Translational Medicine – May 2025

Giusy De Rosa et al.

PMID: 40435218

Intracerebroventricular bivalent CAR T cells targeting EGFR and IL-13Rα2 in recurrent glioblastoma: a phase 1 trial- Nature Medicine – June 2025

Stephen J. Bagley et al.

PMID: 40500416

Biallelic LGI1 and ADAM23 variants cause hippocampal epileptic encephalopathy via the LGI1–ADAM22/23 pathway - Brain – June 2025

Yoko Hirano et al.

PMID: 40455867

Neurodevelopmental origins of structural and psychomotor defects in CXCR4-linked primary immunodeficiency - Neuron – June 2025

Giulia Demenego et al.

PMID: 40482638

Inhibition of acute lung inflammation by a neuroimmune circuit induced by vagal nerve stimulation - Science Advances – June 2025

Kaitlin Murray et al.

PMID: 40465722